I have done just north of 400 miles in one day. Not the most pleasant experience, but not impossible. A few thoughts.
I have a memory foam cushion behind my back which works for me and keeps the pressure well distributed. Took a while to find the right one, but night and day on my back.
Back roads much more relaxing than having massive trucks passing you at speed. I found I could take only so much of that.
Prefer motorcycle glasses to goggles. Less protection I know, but more comfortable.
I always have a good towel handy within reach. Multiple reasons to use at all times.
I always keep a set of wrenches, tape and wire handy. Have replaced the battery in a Walmart parking lot on a long drive. Also, something is always falling off.
Always pack my phone away during a drive so I have no distraction. If I need to figure out where I am I stop. A M3W is a car where I want to be 100 percent engaged and part of the charm is focusing on the driving to the exclusion of all else.
Otherwise, enjoy the most direct and connected drive you can. Free your mind and your M3W will follow.