The drivers which are particular to S&S are loaded onto the computer with the latest version of Protune II. However, unless the computer recognises a connection to the module the drivers will not load into the registry. No internet connection is required.
Ive tried Windows 7, Windows 10 and even a Mac (running a hypervisor) in all cases, once the ECM is powered and recognised the drivers load.
Rebooting may be required once the drivers are loaded. Try a different USB lead, make sure ignition is on