Another option, although I haven’t tried specifically with protune, is to buy Parallels for mac. It allows one to run Windows on a mac. It works great for various other windows-only software.
I dont think this will work as the Protune software will be looking for a Windows method to address USB ports which wont be available on a mac.
I very much doubt a mac emulation will support this.
I have played around with mac windows emulations for other purposes so have experience in this area.
Go windows cheap and cheerful as mentioned above.