Did Warrington - Le Mans round trip a couple of times last year - about 580 miles each way, after 450 miles you start to get a bit buffered and suffering cabin fever !!
350 mile is good, 450 mile is you want a cup of tea at home, 580 mile you got bed sores and ear ache !
I very much agree. I often do 8 hours and have done 12 hours (emergency) but 6 hours is the best. Particularly for the Passenger. Sitting and bouncing for 6 hours is enough.