Touch wood I have never had an issue & I have toured down to S Italy.
Once in the Alps we stopped for lunch & I left the keys in the ignition, but the car was still there on our return.
We use kanulock lockable straps to hold a case on the back.
I fitted a stainless eyebolt to the rear floor of the passenger side & have a stainless cable with soft eyes so I can padlock cases when on the rear shelf.
We have a Librands lockable foot locker.
I usually leave the tonneau closed or the hood up & at night a storm cover.