Will the Centa just bolt right up to the HD Milwaukee 8?
I only works with the '06 and earlier 4-bolt primary to crankcase bolt pattern. In '07 Harley went to a 5-bolt pattern primary.
Also you will need the older crank end with the short splines and threaded crank, not the '07/newer full splined crank with the internal bolt for the compensator.
I don't really know why the S&S Wedge went with the Harley old style bolt pattern, unless they were looking for Harley guys to retro upgrade say an EVO or Shovelhead to a Wedge motor. I don't think I've ever seen that upgrade. Don't even know if they'll fit in the old frames with the new wider "V" design.
The M-8 would be a GREAT motor to throw into a M3W with its twin counterbalance on the Softail models and even the touring single counterbalance motor would be tons smoother than the S&S even with its wider "V" design.