Hi Nielda.... Never noticed any untoward handling issues and all the big 'glides had big front tyres ... Logically you might expect to notice something on bikes with a wide rear tyre and thinner front as they would run more and more 'out of line' as you leaned over.... Never noticed that either when the bike was more 'chopperish' back in the early '80s... So maybe I'm not that observant (or not trying hard enough!). :-)
K