I have not used it in my front tyres but as Rog G says, the instructions say it can be used. I am a bit concerned about balance with the front wheels. I have a can of the spray foam stuff for front wheel punctures, they are easier to get to. I also carry a spare tube, not to replace at the side of the road although some have I believe, but I doubt that many tyre places would have the correct tube if I managed to get to one after a puncture. My front wheel tube would have had the foam inside I expect, so a new tube will be needed and doesn't take up too much space. I have carried one for 7 years now and not needed it, so it may work preventing punctures
