On our trip to Austria last year, 250 miles in a day was straightforward and allowed plenty of time for comfort stops, sight seeing and meals. 300 was a bit too much and we ended up using motorways to keep journey times within bounds. The fundamental issue is the person in the passenger seat. My nagivator starts to get verbose after too long on the car. Planning this year’s trip to the Pyrenees we have tried to keep every day under 250 miles - it is meant to be a holiday.
And another vote for leaving side screens on for the longer days - it is important that you are still talking to each other when you get that post drive cold beer at the end of the day. I have now dispensed with the side screen storage luggage rack and replaced it with a low-line luggage rack which gives me much better rear visibility with luggage in place. The side screen storage rack sits in the garage and will be re-installed for days out locally when just carrying picnic chairs etc.